Trans-synaptic interactions of ionotropic glutamate receptors

Trans-synaptic interactions organize the multiple steps of synaptic development and are critical to generate fully functional neuronal circuits. While trans-synaptic primarily mediated by cell adhesion molecules (CAMs), some directly involve ionotropic glutamate receptors (iGluRs). Here, we review expanding extracellular proteome iGluRs. We discuss role these molecular networks in specifying formation excitatory inhibitory circuits input-specific recruitment iGluRs at synapses various types brain regions. also shed light on human-specific mutations affecting iGluR-mediated that may provide unique features human contribute its susceptibility neurodevelopmental disorders. Together, data support a view which iGluR function goes far beyond fast transmission shaping wiring properties neural